| 发明名称 |
MACROCYCLIC COMPOUNDS AS TRK KINASE INHIBITORS |
| 摘要 |
<p>Compounds of Formula I :
and pharmaceutically acceptable salts thereof, wherein ring A, ring B, W, m, D, R 2 , R 2a , R 3 , R 3a , and Z are as defined herein, are inhibitors of Trk kinases and are useful in the treatment of pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases.</p> |
| 申请公布号 |
EP2571883(B1) |
申请公布日期 |
2015.01.07 |
| 申请号 |
EP20110728970 |
申请日期 |
2011.05.13 |
| 申请人 |
ARRAY BIOPHARMA, INC. |
发明人 |
ANDREWS, STEVEN, WADE;CONDROSKI, KEVIN, RONALD;HAAS, JULIA;JIANG, YUTONG;KOLAKOWSKI, GABRIELLE, R.;SEO, JEONGBEOB;YANG, HONG-WOON;ZHAO, QIAN |
| 分类号 |
C07D471/22;C07D487/04;C07D498/22;C07D519/00 |
主分类号 |
C07D471/22 |
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