A TRANSGENIC MOUSE FOR DIAGNOSIS OR TREATMENT OF AGE-RELATED DISORDER OR DISEASE COMPRISING A KNOCK-OUT P62 GENE AND A METHOD OF SCREENING FOR A COMPOUND THAT COUNTERS AGE-RELATED DISORDER OR DISEASE USING THE SAME

摘要

A transgenic mouse for diagnosis or treatment of age-related disorder or disease comprising a knock-out p62 gene and a method of screening for a compound that counters age-related disorder or disease using the same are provided to be useful for the screening in a research for age-related disorder. A method of screening for a compound that counters age-related disorder or disease using the same includes the steps of: treating a test compound to be screened in a mouse somatic cell; measuring the degree of disorder after processing the compound; and comparing the measured degree of disorder as a control group with the degree of disorder in the somatic cell that is not treated with a test compound. The reduction in the degree of the disorder that is related to aging that is compared with the control group in the second step indicates that the compound counters the disorder relating to aging.