| 摘要 |
FIELD: chemistry. ^ SUBSTANCE: invention pertains to the method of obtaining derivatives of substituted imidazole with general formula (I) and their acid-additive salts, where Y represents -CH2- or -CO-, R1 represents H, halogen or hydroxyl, R2 represents H or halogen, and R3 represents H or low alkyl. The method involves the following stages: a) halogenation of formula II compound, in which Y, R1 R2 and R3 assume values given above, with use of formula III compound, in which Y, R1 R2 and R3 assume values give above, and X represents a halogen atom, b) reaction of the obtained formula III compound with an amine with formula R4NH2, in which R4 represents an easily removable leaving group, and thiocyanate of an alkaline metal with obtaining of formula IV compound, in which Y, R1 R2, R3 and R4 assume the values given above, c) removal of the mercapto group from the formula IV compound with obtaining of formula V compound, in which Y, R1 R2, R3 and R4 assume values give above, d) removal of R4 group from formula V compound with obtaining of formula I compound, and if desired, e) conversion of the obtained formula I compound to its acid-additive salt. The invention also relates to intermediate compounds and the method of obtaining them. ^ EFFECT: method of obtaining formula I compound with good output and large-scale process. ^ 20 cl, 6 ex |
