发明名称 |
PROTEOMIC ANALYSIS OF CERVICAL-VAGINAL FLUIDS FOR DETECTING INTRA-UTERINE INFECTION OR DETERMINING PRE-TERM DELIVERY RISK IN A PREGNANT FEMALE |
摘要 |
The invention concerns the identification of proteomes of biological fluids and their use in determining the state of maternal/fetal conditions, including maternal conditions of fetal origin, chromosomal aneuploidies, and fetal diseases associated with fetal growth and maturation. In particular, the invention concerns a comprehensive proteomic analysis of human amniotic fluid (AF) and cervical vaginal fluid (CVF), and the correlation of characteristic changes in the normal proteome with various pathologic maternal/fetal conditions, such as intra-amniotic infection, pre-term labor, and/or chromosomal defects. The invention further concerns the identification of biomarkers and groups of biomarkers that can be used for non-invasive diagnosis of various pregnancy-related disorders, and diagnostic assays using such biomarkers. |
申请公布号 |
WO2008063928(A3) |
申请公布日期 |
2008.09.12 |
申请号 |
WO2007US84311 |
申请日期 |
2007.11.09 |
申请人 |
PROTEOGENIX, INC.;ROSENFELD, RON;NAGALLA, SRINIVASA;GRAVETT, MIKE |
发明人 |
ROSENFELD, RON;NAGALLA, SRINIVASA;GRAVETT, MIKE |
分类号 |
G01N33/68 |
主分类号 |
G01N33/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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