BENZOTROPOLONE DERIVATIVES POSSESSING ANTI HIV-ACTIVITY, PHARMACEUTICAL COMPOSITION; METHOD OF HIV-INTEGRASE INHIBITION

摘要

FIELD: chemistry. ^ SUBSTANCE: present invention refers to the new benzotropolone derivatives of general structural formula (A) as well to their pharmaceutically acceptable salts possessing anti hiv-activity, to the pharmaceutical composition thereof and to the method of HIV-integrase inhibition. formula (A) where R1 is selected from the group consisting of the hydrogen and halogen; R2 is selected from the group consisting of the hydrogen and OC1-6alkyl; each of R3, R4, R5 independently is hydrogen; G is selected from the group consisting of the structures I, II; R6 is hydrogen; R7 is COOR9; R8 is selected from C1-6alkyls substituted with one or more halogen atoms; W is O; R9 is selected from hydrogen or C1-6alkyl. The structures I, II are represented in the formula of invention. ^ EFFECT: claimed compounds possess anti HIV-activity. ^ 5 cl, 6 dwg, 13 ex