Compounds for breast cancer treatment

摘要

The present invention is related to 1-benzyl-3-(substituted aryl) condensed pyrazoles and compositions thereof for their use in the treatment of breast cancer, in particular in the treatment of breast cancer resistant to endocrine therapy. The compounds preferably are YC-1 or BAY 41-2272. Optionally, estrogen receptor antagonists, selective estrogen receptor modulators, aromatase inhibitors, ErbB3 inhibitors, EGFR inhibitors and/or mTOR inhibitors are coadministered.