| 发明名称 |
NEPRILYSIN INHIBITOR |
| 摘要 |
PROBLEM TO BE SOLVED: To provide a compound having neprilysin inhibition activity, further a pharmaceutical composition containing the compound, a method of using the compound and a process and an intermediate for preparing the compound.SOLUTION: There is provided a compound represented by the formula (I) or a pharmaceutically acceptable salt thereof.EFFECT: The above described compound is useful and advantageous as a therapeutic agent for treating conditions such as hypertension and cardiac failure because it was found that the compound has a neprilysin (NEP) catalyst inhibition activity.SELECTED DRAWING: None |
| 申请公布号 |
JP2016104784(A) |
申请公布日期 |
2016.06.09 |
| 申请号 |
JP20160001113 |
申请日期 |
2016.01.06 |
| 申请人 |
THERAVANCE BIOPHARMA R&D IP LLC |
发明人 |
MELISSA FLEURY;GENDRON ROLAND;ADAM D HUGHES;JANE SCHMIDT |
| 分类号 |
C07D237/04;A61K31/341;A61K31/4192;A61K31/4196;A61K31/42;A61K31/421;A61K31/437;A61K31/44;A61K31/4965;A61K31/50;A61K31/505;A61K31/5365;A61K31/553;A61P9/04;A61P9/12;A61P13/12;A61P43/00;C07D213/81;C07D239/28;C07D241/24;C07D249/04;C07D249/10;C07D249/18;C07D261/18;C07D263/34;C07D307/68;C07D471/04;C07D498/04 |
主分类号 |
C07D237/04 |
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