Catalytic domains from lysyl oxidase and LOXL2

摘要

Disclosed herein are amino acid sequences, and encoding nucleotide sequences, of isolated catalytic domains of the LOX and LOXL2 proteins from human and mouse. Methods for the preparation and use of these isolated catalytic domains are also provided.

主权项

1. An isolated polynucleotide, comprising: a nucleotide sequence encoding a polypeptide comprising a catalytic domain of a human LOX protein, wherein: the said polynucleotide is a cDNA and wherein the polypeptide comprises the amino acid sequence selected from the group consisting of: SEQ ID NO: 1 and SEQ ID NO: 1 without the initial GL residues, and the polypeptide does not contain sequences from the human LOX protein outside its catalytic domain.