Sustained release preparation of pro-insulin C-peptide

摘要

The present invention provides a pharmaceutical composition for the sustained release of C-peptide. The composition is in the form of a gel containing C-peptide. The gel formation is achieved by the adjustment of pH of the composition and/or by addition of divalent metal ions. The composition does not include any other gel-forming agents. Methods for producing the composition, medical uses of the composition and products containing two or more gel compositions as a combined preparation are also encompassed.

主权项

1. A pharmaceutical composition for the sustained release of C-peptide said composition being in the form of a gel comprising colloidal C-peptide,
wherein said C-peptide is full length as disclosed in SEQ. ID. Nos. 1-24, or a fragment of each one thereof comprising residues 15-31 when at least 31 residues are present, or as disclosed in SEQ. ID. Nos. 25-31, wherein gel formation is induced by the adjustment of pH of said composition and/or by addition of divalent metal ions, and wherein said composition does not include any gel-forming agents, other than metal ions, if present.