发明名称 |
MÉTODO PARA DETERMINAR A ATIVIDADE DO FATOR VON WILLEBRAND NA AUSÊNCIA DE RISTOCETINA E PARA DETERMINAR A ADAMTS-13 PROTEASE |
摘要 |
Determining von Willebrand factor activity comprises mixing a sample with a human GPIbalpha protein (I) having amino acid substitutions at positions 233 and 239 and not adding ristocetin or botrocetin. Independent claims are also included for: (1) test kit for an assay as above, comprising (I) on a nonparticulate solid phase; (2) producing (I) by expressing (I) recombinantly in a prokaryotic or eukaryotic cell culture and isolating (I) from a cell lysate or culture supernatant by affinity chromatography. |
申请公布号 |
BRPI0814056(A2) |
申请公布日期 |
2015.01.06 |
申请号 |
BR2008PI14056 |
申请日期 |
2008.07.03 |
申请人 |
SIEMENS HEALTHCARE DIAGNOSTICS PRODUCTS GMBH |
发明人 |
HARALD ALTHAUS;TOBIAS OBSER;JUERGEN PATZKE;REINHARD SCHNEPPENHEIM |
分类号 |
G01N33/86;C12Q1/37 |
主分类号 |
G01N33/86 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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