发明名称 |
ANTI-GLYPICAN 3 ANTIBODY HAVING MODIFIED SUGAR CHAIN |
摘要 |
An anti-glypican 3 antibody with modified sugar chains, more specifically, an anti-glypican 3 antibody lacking fucose is provided. The anti-glypican 3 antibody with modified sugar chains of the present invention may be produced by a process comprising introducing a nucleic acid encoding an anti-glypican 3 antibody into host cells with reduced fucose addition capability, such as YB2/0 cells and cells lacking a fucose transporter. The anti-glypican 3 antibody with modified sugar chains of the present invention has a high level of cytotoxic activity and therefore is useful as a cell growth inhibitor such as an anticancer agent. |
申请公布号 |
CA2585196(C) |
申请公布日期 |
2015.01.06 |
申请号 |
CA20052585196 |
申请日期 |
2005.10.26 |
申请人 |
CHUGAI SEIYAKU KABUSHIKI KAISHA |
发明人 |
NAKANO, KIYOTAKA;SUGO, IZUMI;SUGIMOTO, MASAMICHI;ISHIGURO, TAKAHIRO;TANAKA, MEGUMI;IIJIMA, SHIGEYUKI |
分类号 |
C07K16/18;A61K39/395;A61P35/00;C12N15/09;C12P21/08 |
主分类号 |
C07K16/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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