Compounds from soft coral, method of preparation and pharmaceutical uses thereof

摘要

The invention relates to compounds from the soft coral and the generation thereof. The invention also relates to the uses of the compounds from the soft coral in inhibiting inducible nitric oxide synthase and/or cyclooxygenase-2 and in treating the diseases associated with inducible nitric oxide synthase and/or cyclooxygenase-2.

主权项

1. A method for preparing a purified compound represented by the following formula, R1 is selected from the group consisting of —H, —OH, —OC(═O)R11, —OOH, and OAc; R2 is selected from the group consisting of —S(C═O)CH3 and —OH; R3 is selected from the group consisting of —CH3 and —OH; R4 is selected from the group consisting of —OH and —OAc; R5 is selected from the group consisting of —H, —OAc, and —OC(═O)CH2CH2CH3; R6 is selected from the group consisting of —H, —OC(—O)CH2CH2CH3, OC(═O)CH2CH2S(═O)CH3, and —OAc; R7 is selected from the group consisting of —H, —OAc, and ═O; R8 is —H; R9 is —OC(═O)CH2CH2CH3; R10 is —CH3; R11 is an alkyl group; and B is a single bond; or R1 and R1 together form the group consisting of —O— and a double bond; or R2 and R3 together form ═CH2, R4 is OH and R6 is OAc; or R7 and R8 together form —O—; or R8 and R9 together form a double bond; or R1 and R8 together form —O—; or R9 and R10 together form ═CH2; or R2 and R8 together form a single bond; or R2 and B together form ═O and R1 and B together form ═O; wherein the compound is not the compound represented by the following formula 17 or 18; comprising obtaining the compound from an extract of cultured Klyxum simplex.