Thromboxane A2 (TP) receptor antagonists

摘要

The present invention relates to novel TP receptor antagonists, which optionally cross the blood-brain barrier of a mammal. The invention also provides methods for treating a disorder related to activation of TP receptor utilizing the compounds of the invention.

主权项

1. A composition comprising a compound of Formula (I), or a salt or solvate thereof:wherein:
R1 is selected from the group consisting of the bond between carbons 1 and 2 is either a single bond (C1-C2) or a double bond (C1═C2); R2 is selected from the group consisting of F, Cl, Br, I, and CF3; R3 is selected from the group consisting of NR4, S, and O; R4 is selected from the group consisting of H, —(C1-C6 alkyl), —(C1-C6 fluoroalkyl), —(C1-C6 heteroalkyl), —(C1-C3 alkyl)-(C3-C6 cycloalkyl), —(C1-C3 alkyl)-aryl, —(C1-C3 alkyl)-heteroaryl, —C(═O)R5, —CO2R5, and —CH(R)2; and, each occurrence of R5 is independently selected from the group consisting of H, —(C1-C6 alkyl), —(C1-C6 heteroalkyl), and —(C1-C3 alkyl)-(C3-C6 cycloalkyl), wherein the alkyl, heteroalkyl, or cycloalkyl group is optionally substituted.