Embedded chimeric peptide nucleic acids and uses thereof

摘要

The present invention relates to an ecPNA having the general structure:
H2N—X—B—Y—COOH
and uses thereof, wherein X is A or C and Y is A or C with the proviso that when X is A, Y is C, and when X is C, Y is A; A represents an oligopeptide structure, the sequence of which comprises a sequence which renders the compound able to enter the nucleus of a cell; B represents a peptide nucleic acid (PNA) structure at least 12 nucleotides in length, the sequence of which is capable of hybridizing with a DNA within the nucleus of the cell, which DNA is within a promoter region of a gene; C represents an oligopeptide structure; and each — represents a chemical linkage between the structures at each side thereof, which may be the same as or different from each other such linkage.

主权项

1. An embedded chimeric peptide nucleic acid (ecPNA) having the structure H2N-CGSDALDDFDLDML-Biotin-O-TACTCTAAGACTATT-O-YGRKKRRQRRR, wherein each — is a chemical bond.