Therapeutic agent and diagnostic agent for mitochondrial dysfunction brain diseases

摘要

To provide a therapeutic agent and a diagnostic agent for mitochondrial dysfunction brain diseases including cerebral infarction as a representative.;A therapeutic agent for a mitochondrial dysfunction brain disease, which comprises (A) δ-aminolevulinic acid represented by the formula (1), a derivative thereof, or a salt thereof and (B) an iron compound in combination.
R2R1NCH2COCH2CH2COR3  (1)
wherein R1 and R2 each independently represents a hydrogen atom, an alkyl group, an acyl group, an alkoxycarbonyl group, an aryl group, or an aralkyl group; and R3 represents a hydroxy group, an alkoxy group, an acyloxy group, an alkoxycarbonyloxy group, an aryloxy group, an aralkyloxy group, or an amino group.

主权项

1. A method for treating a mitochondrial dysfunction brain disease selected from the group consisting of Parkinson's Disease, Alzheimer's Disease, atherothrombotic cerebral infarction, cerebral ischemia at surgery and intravascular surgery, comprising administering to a subject, an effective amount of a therapeutic agent which comprises:
(A) a δ-aminolevulinic acid represented by the formula (1), a derivative thereof, or a salt thereof:
R2R1NCH2COCH2CH2COR3  (1) wherein R1 and R2 each independently represents a hydrogen atom, an alkyl group, an acyl group, an alkoxycarbonyl group, an aryl group, or an aralkyl group; and R3 represents a hydroxy group, an alkoxy group, an acyloxy group, an alkoxycarbonyloxy group, an aryloxy group, an aralkyloxy group, or an amino group, and (B) an iron compound.