| 发明名称 |
Differentiation of human embryonic and induced pluripotent stem cells |
| 摘要 |
The invention relates to culture systems, methods, and conditions that allow pluripotent undifferentiated hESCs or iPSCs to progressively and uniformly differentiate into cells of the chondrogenic lineage. |
| 申请公布号 |
US8927275(B2) |
申请公布日期 |
2015.01.06 |
| 申请号 |
US201313735742 |
申请日期 |
2013.01.07 |
| 申请人 |
University of Connecticut |
发明人 |
Dealy Caroline;Kosher Robert |
| 分类号 |
C12N5/00;C12N5/077 |
主分类号 |
C12N5/00 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An isolated population of chondrogenic cells, wherein at least 85% of said cells are at a single defined stage of chondrogenic differentiation, and wherein the isolated population of chondrogenic cells exhibits an increased level of Sox9 and Brachyury expression compared to a population of fully differentiated chondrocytes and exhibits a reduced level of aggrecan expression compared to a population of fully differentiated chondrocytes. |
| 地址 |
Farmington CT US |
