| 摘要 |
Devices, methods and systems facilitate and enable vessel wall treatment, particularly at the neck of an aneurysm. A tethered cage-like structure functions in conjunction with supplemental therapies such as a vaso-occlusive coil delivering microcatheter system and/or pharmaceutical delivery, among other things, by stabilizing vessel walls and providing tethered cage-like therapeutic support for treating aneurysms, temporarily or on an implantable basis. |
| 主权项 |
1. An improved system for bridging aneurysms in neurovasculature, the system comprising:
a first microcatheter for accessing neurovascular vessels over a guidewire; a variable stiffness delivery tube comprising a proximal section and a distal section, wherein said distal section has a decreased stiffness and a greater flexibility as compared to the proximal section to allow tracking through tortuous anatomy of the neurovasculature, wherein said variable stiffness delivery tube comprises an internal lumen configured to receive a guidewire, said guidewire providing trackability, maintained access and vessel support; and a tethered cage-like structure eccentrically coupled to said delivery tube via a plurality of tethers such that the tethered cage-like structure is temporary and configured for removal from a patient's body, wherein said cage-like structure has an open proximal end, an open distal end, and a tapering portion, the tapering portion located between the plurality of tethers and the open distal end, the tapering portion tapering, in absence of external forces, between a proximal end of the tapering portion and the open distal end such that said cage-like structure has a first circumference at the proximal end of the tapering portion and a second circumference, smaller than the first circumference, at the open distal end, wherein said cage-like structure comprises a plurality of struts and a plurality of openings formed between the struts to provide vessel support without obstructing blood flow, wherein said cage-like structure can be delivered to a target site local to an aneurysm and positioned to bridge the neck of the aneurysm, thereby covering the aneurysm to reconstruct a vessel wall; and whereby a second microcatheter can be threaded through one or more open cells of the cage-like structure for delivery of supplemental therapy to the aneurysm while maintaining revascularization. |
