Microcrystalline Y receptor agonists

摘要

The disclosure provides microcrystals of Y receptor agonists; microcrystalline pellets of Y receptor agonists, and microcrystalline suspensions of Y receptor agonists. Pharmaceutical compositions containing these microcrystals, microcrystalline pellets, and microcrystalline suspensions have prolonged pharmacokinetic profiles making them useful for once daily or once weekly administration.

主权项

1. A microcrystal comprising a Y receptor agonist peptide, wherein the microcrystal has a particle size of about 1 micron to about 15 microns and is birefringent when viewed under a polarized light microscope, wherein the Y receptor agonist peptide comprises the amino acid sequence of any one of SEQ ID NOs: 1-483.