| 发明名称 | Method for producing hyaluronic acid | ||
| 摘要 | It is intended to provide a simple method for producing hyaluronic acid at a high yield. Further, it is also intended to provide a method for producing hyaluronic acid in a short period of time. The invention provides a method for producing hyaluronic acid including a step of culturing a microorganism having the capability to produce hyaluronic acid and a step of adding glutamine and arginine to a culture medium during late logarithmic growth phase of the microorganism. | ||
| 申请公布号 | US8927234(B2) | 申请公布日期 | 2015.01.06 |
| 申请号 | US200813055628 | 申请日期 | 2008.07.25 |
| 申请人 | Denki Kagaku Kogyo Kabushiki Kaisha | 发明人 | Hashimoto Masamichi;Kakema Teruaki;Fujii Kenji;Ikemi Masahisa |
| 分类号 | C12P19/26;C08B37/00;C08B37/08 | 主分类号 | C12P19/26 |
| 代理机构 | Stein IP, LLC | 代理人 | Stein IP, LLC |
| 主权项 | 1. A method for producing hyaluronic acid comprising culturing a microorganism having the capability of producing hyaluronic acid in a culture medium wherein said microorganism is Streptococcus equi, Streptococcus equi mutant strain FM-100 (Fermentation Research Institute, the Agency of Industrial Science and Technology, Deposit No. 9027) or Streptococcus equi mutant strain FM-300 (Fermentation Research Institute, the Agency of Industrial Science and Technology, Deposit No. 2319), adding glutamine and arginine to the culture medium during late logarithmic growth phase of the microorganism and producing hyaluronic acid. | ||
| 地址 | Tokyo JP | ||