Operator-controlled scanning laser procedure designed for large-area epithelium removal

摘要

Systems and methods for removing an epithelial layer disposed over a stromal layer in a cornea irradiate a region of the epithelial layer with a pulsed beam of ablative radiation. The ablative radiation is scanned to vary the location of the beam within the region in accordance with a pulse sequence. The pulse sequence is arranged to enhance optical feedback based on a tissue fluorescence of the epithelial layer. The penetration of the epithelial layer is detected in response to the optical feedback. The use of scanning with the pulse sequence arranged to enhance optical feedback allows large areas of the epithelium to be ablated such penetration of the epithelial layer can be detected.

主权项

1. A method for removing an epithelial layer disposed over a stromal layer in a cornea, the method comprising: irradiating a region of the epithelial layer with a pulsed beam of an ablative radiation; scanning the ablative radiation by moving a location of the beam within the region in accordance with a pulse sequence, wherein the pulse sequence is arranged in response to a plurality of epithelial layer ring shaped basis profiles, wherein at least some of the plurality of ring shaped basis profiles each comprise a central portion corresponding to no ablation, wherein the pulsed beam of the ablative radiation removes the epithelial layer to expose at least one of the stromal layer or a bowman's membrane.