Devices, formulations, and methods for delivery of multiple beneficial agents

摘要

The present invention relates to osmotic delivery devices, formulations, and methods for delivery of two or more beneficial agents. In one aspect, the present invention provides osmotic delivery devices useful for substantially concurrent administration of two or more beneficial agents. In another aspect, the present invention provides beneficial agent formulations for use in the osmotic delivery devices. The formulations include formulations wherein beneficial agents are soluble in the vehicle, suspension formulations comprising particle formulations of one or more beneficial agent, and combinations thereof. Further, methods for treatment of a variety of diseases or conditions using two or more beneficial agents are disclosed, wherein the methods are preferably practiced using the osmotic delivery devices and/or formulations of the invention.

主权项

1. An osmotic delivery device comprising:
a beneficial agent formulation comprising (i) a non-aqueous, viscous vehicle comprising a solvent and a polymer, the vehicle having a viscosity of between about 12,000 to about 18,000 poise at 33° C., and (ii) a particle formulation comprising two or more polypeptides, wherein the two or more polypeptides are selected from the group consisting of GLP-1, exendin-4, PYY, and oxyntomodulin; wherein the particle formulation is suspended in the non-aqueous, viscous vehicle.