| 发明名称 |
Fibronectin based scaffold domain proteins that bind IL-23 |
| 摘要 |
The present invention relates to fibronectin based scaffold domain protein that bind interleukin 23 (IL-23), specifically the p19 subunit of IL-23. The invention also relates to the use of the innovative proteins in therapeutic applications to treat autoimmune diseases. The invention further relates to cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative proteins. |
| 申请公布号 |
US8927693(B2) |
申请公布日期 |
2015.01.06 |
| 申请号 |
US201113579204 |
申请日期 |
2011.02.16 |
| 申请人 |
Bristol-Myers Squibb Company |
发明人 |
Dasgupta Ruchira;Bush Alex;Schneeweis Lumelle;Engle Linda |
| 分类号 |
C07K14/00;C07K14/78;C12N15/10;A61K38/00 |
主分类号 |
C07K14/00 |
| 代理机构 |
|
代理人 |
Parlet Nickki L. |
| 主权项 |
1. A polypeptide comprising a fibronectin type III tenth domain (10Fn3) shown in SEQ ID NO:1, wherein the 10 Fn3 comprises a BC loop selected from SEQ ID NO:2-6, a DE loop selected from SEQ ID NO:7-48, and a FG loop selected from SEQ ID NO:49-59 and wherein the polypeptide binds the structural epitope of the p19 subunit of IL-23. |
| 地址 |
Princeton NJ US |
