Transducible polypeptides for modifying metabolism

摘要

Methods and compositions for modifying the metabolism of a subject are provided. One embodiment provides a recombinant polypeptide having a polynucleotide-binding domain, a protein transduction domain, and a targeting domain. In a preferred embodiment, the polynucleotide-binding domain includes one or more HMG box domains.

主权项

1. A fusion protein comprising a protein transduction domain, a mitochondrial localization signal and the mature Transcription Factor A-mitochondrial (TFAM) of SEQ ID NO:20.