Use of nitrite salts for the treatment of cardiovascular conditions

摘要

It has been surprisingly discovered that administration of nitrite to subjects causes a reduction in blood pressure and an increase in blood flow to tissues. The effect is particularly beneficial, for example, to tissues in regions of low oxygen tension. This discovery provides useful treatments to regulate a subject's blood pressure and blood flow, for example, by the administration of nitrite salts. Provided herein are methods of administering a pharmaceutically-acceptable nitrite salt to a subject, for treating, preventing or ameliorating a condition selected from: (a) ischemia-reperfusion injury (e.g., hepatic or cardiac or brain ischemia-reperfusion injury); (b) pulmonary hypertension (e.g., neonatal pulmonary hypertension); or (c) cerebral artery vasospasm.

主权项

1. A method for treating cerebral artery vasospasm in a subject, comprising injecting a therapeutically effective amount of non-acidified sodium nitrite to said subject whereby the non-acidified sodium nitrite contacts blood in the subject, wherein the sodium nitrite is administered to a circulating concentration of about 0.6 to 240 μM, thereby treating cerebral artery vasospasm in the subject.