发明名称 |
Isotope preparation method |
摘要 |
The present invention provides a method for the generation of 223Ra of pharmaceutically tolerable purity comprising i) preparing a generator mixture comprising 227Ac, 227Th and 223Ra; ii) loading said generator mixture onto a strong base anion exchange resin; iii) eluting said 223Ra from said strong base anion exchange resin using a first mineral acid in an alcoholic aqueous solution to give a first eluted 223Ra solution; iv) loading the 223Ra of the first eluted 223Ra solution onto a strong acid cation exchange resin; and v) eluting the 223Ra from said strong acid cation exchange resin using a second mineral acid in aqueous solution to provide a second eluted solution. The invention additionally provides products of corresponding purity and/or products obtained or obtainable by such a method. |
申请公布号 |
US8926943(B2) |
申请公布日期 |
2015.01.06 |
申请号 |
US201113695353 |
申请日期 |
2011.04.29 |
申请人 |
Algeta ASA |
发明人 |
Karlson Jan Roger;Børretzen Peer |
分类号 |
A61K51/00;A61K51/02;C01F13/00;A61K51/12;G21G1/00 |
主分类号 |
A61K51/00 |
代理机构 |
Clark & Elbing LLP |
代理人 |
Clark & Elbing LLP |
主权项 |
1. A method for the generation of 223Ra of pharmaceutically tolerable purity comprising
i) preparing a generator mixture comprising 227Ac, 227Th and 223Ra; ii) loading said generator mixture onto a strong base anion exchange resin; iii) eluting said 223Ra from said strong base anion exchange resin using a first mineral acid in an alcoholic aqueous solution to give a first eluted 223Ra solution; iv) loading the 223Ra of the first eluted 223Ra solution onto a strong acid cation exchange resin; and v) eluting the 223Ra from said strong acid cation exchange resin using a second mineral acid in aqueous solution to provide a second eluted solution, wherein said 223Ra of pharmaceutically tolerable purity comprises less than 45Bq 227Ac per MBq 223Ra. |
地址 |
Oslo NO |