| 摘要 |
<p>The present invention relates to a water-soluble anticancer drug composed of a heparin-docetaxel conjugate and to a method for preparing the same and, more specifically, to a water-soluble anticancer drug in which a spherical nanoparticle is formed of a conjugate having aminized docetaxel self-aggregated on low-molecular weight heparin, and a hydrophilic segment of the heparin is introduced on a surface of the nanoparticle, and to a method for preparing the water-soluble anticancer drug, comprising the steps of removing a sodium salt from low-molecular heparin; introducing an amine group to docetaxel; mixing the sodium salt-removed heparin and the docetaxel with the introduced amine group to self-aggregate the mixture; and purifying the self-aggregated heparin-docetaxel conjugate. According to the present invention, provided can be a water-soluble anticancer drug capable of overcoming the low solubility of docetaxel in water, improving the administrability of heparin, and expecting a synergy effect of simultaneously applying anticancer activity of docetaxel and anticancer activity of heparin.</p> |
