发明名称 |
Treatment of Heart Failure and Sudden Cardiac Death |
摘要 |
A method of reducing heart failure or preventing sudden cardiac death in a subject in need thereof is carried out by administering a composition comprising a compound that increases cellular level of Sarco/endoplasmic reticulum Ca2+-ATPase 2a (SERCA2a). The invention represents a significant breakthrough in the treatment or prevention of chronic heart failure. The invention is based upon the discovery that a Mifepristone molecule increases the cellular level of SERCA2a protein. |
申请公布号 |
US2015005269(A1) |
申请公布日期 |
2015.01.01 |
申请号 |
US201314370126 |
申请日期 |
2013.01.03 |
申请人 |
Rhode Island Hospital |
发明人 |
Koren Gideon;Zheng Zhe |
分类号 |
A61K31/575;A61K45/06 |
主分类号 |
A61K31/575 |
代理机构 |
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代理人 |
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主权项 |
1. A composition for reducing heart failure in a subject in need thereof, comprising a compound that increases cellular level of Sarco/endoplasmic reticulum Ca2+-ATPase 2a (SERCA2a). |
地址 |
Providence RI US |