| 发明名称 |
Tumorspecific SPECT/MR(T1), SPECT/MR(T2) and SPECT/CT contrast agents |
| 摘要 |
The invention relates to cancer receptor-specific bioprobes for single photon emission computed tomography (SPECT) and computed tomography (CT) or magnetic resonance imaging (MRI) for dual modality molecular imaging. The base of the bioprobes is the self-assembled polyelectrolytes, which transport gold nanoparticles as CT contrast agents, or SPION or Gd(III) ions as MR active ligands, and are labeled using complexing agent with technetium-99m as SPECT radiopharmacon. Furthermore these dual modality SPECT/CT and SPECT/MR contrast agents are labeled with targeting moieties to realize the tumorspecificity. |
| 申请公布号 |
US2015004096(A1) |
申请公布日期 |
2015.01.01 |
| 申请号 |
US201314133975 |
申请日期 |
2013.12.19 |
| 申请人 |
BORBÉLY János;HAJDU István;BODNÁR Magdolna;CSIKÓS Zsuzsanna |
发明人 |
BORBÉLY János;HAJDU István;BODNÁR Magdolna;CSIKÓS Zsuzsanna |
| 分类号 |
A61K51/12;A61K51/06 |
主分类号 |
A61K51/12 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A targeting SPECT/CT nanoparticulate tumorspecific contrast composition comprising (i) at least two, preferably water-soluble, biocompatible and biodegradable nanoparticle polyelectrolyte biopolymers; (ii) a targeting molecule conjugated a polyanion biopolymer; (iii) gold nanoparticles coated by the polyelectrolyte biopolymer, (iv) optionally a complexing agent conjugated to the polyelectrolyte biopolymer, and (v) a radionuclide, preferably technetium-99m complexed to the nanoparticles. |
| 地址 |
Debrecen HU |
