| 发明名称 |
Polypeptides Targeting Vascular Endothelial Growth Factor Receptor-2 and Alpha V Beta 3 Integrin |
| 摘要 |
Polypeptides comprising variant vascular endothelial growth factor sequences are provided. The polypeptides are useful in cancer imaging, cancer diagnosis, monitoring and treatment as well as treatment of diseases characterized by excessive neovascularization. |
| 申请公布号 |
US2015005235(A1) |
申请公布日期 |
2015.01.01 |
| 申请号 |
US201414476551 |
申请日期 |
2014.09.03 |
| 申请人 |
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY |
发明人 |
Cochran Jennifer R.;Silverman Adam;Jones Douglas;Papo Niv |
| 分类号 |
C07K14/475 |
主分类号 |
C07K14/475 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A vascular endothelial growth factor (VEGF) variant polypeptide, comprising:
(a) a first polypeptide encoding VEGF, and (b) a second polypeptide encoding an integrin-recognition RGD motif containing loop; wherein the VEGF variant polypeptide is a single-chain. |
| 地址 |
PALO ALTO CA US |
