PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING COGNITIVE IMPAIRMENT-RELATED DISEASE COMPRISING MORPHOLINE OR PIPERAZINE BASED COMPOUNDS, AND DONEPEZIL

摘要

Provided is a pharmaceutical composition for preventing or treating a cognitive impairment-related disease, the pharmaceutical composition including N-(2-hydroxyethyl)piperazine-N′(3-propane sulfonic acid), a pharmaceutically acceptable salt thereof or a derivative thereof, and donepezil, a pharmaceutically acceptable salt thereof or a derivative thereof. The composition may be used in preventing or treating a cognitive impairment-related disease.

主权项

1. A pharmaceutical composition for preventing or treating a cognitive impairment-related disease, the pharmaceutical composition comprising a morpholine compound or a piperazine compound represented by Formula 1 below and comprising a sulfonic acid structure or a carboxylic acid structure, a pharmaceutically acceptable salt thereof, or a derivative thereof; and donepezil, a pharmaceutically acceptable salt thereof, or a derivative thereof: in Formula 1, Z is O or N; when Z=O, R1 is not bonded and when Z=N, R1 is —(CH2)n—OH; and R2 is —(CH2)n—R3, n is an integer selected from 1 to 5, and R3 is —COON or —SO3H.