MACROMOLECULE DELIVERY TO NANOWELLS

摘要

Provided herein is technology relating to depositing and/or placing a macromolecule at a desired site for an assay and particularly, but not exclusively, to methods and systems for transporting a macromolecule such as a protein, a nucleic acid, or a protein:nucleic acid complex to an assay site, such as the bottom of a nanopore, a nanowell, or a zero mode waveguide.

主权项

1. A composition for transporting a macromolecule to a site, wherein the composition comprises:
a) a transport guide; b) a molecular motor that binds to and moves along the transport guide; and c) a macromolecule comprising a linking domain, wherein the linking domain links the macromolecule to the molecular motor.