发明名称 |
INTEGRATED COMPOUND DISCOVERY SYSTEMS AND METHODS |
摘要 |
Methods, systems, devices and apparatus for use in screening and/or selecting a library of nucleic acid molecules and/or nucleic acid tagged or encoded molecules for binding to or interaction with a target molecule or substance (e.g., for use in new compound or drug discovery) are described. In some embodiments the device comprises: (a) a spatially addressable array, said array comprising a plurality of separate and discrete locations thereon; (b) a plurality of different oligomers operably connected to said spatially addressable array at different ones of said separate and discrete locations; (c) a tag sequence which is complementary to, and is hybridized to, each of said oligomers; and (d) a candidate chemical operably connected to each of said tag sequences, wherein each of said discrete locations is a unique identifier for its corresponding oligomer; and wherein said tag sequence is a unique identifier for its connected candidate chemical. |
申请公布号 |
US2015005178(A1) |
申请公布日期 |
2015.01.01 |
申请号 |
US201214346362 |
申请日期 |
2012.12.21 |
申请人 |
NanoMedica LLC ;Wake Forest University |
发明人 |
Bonin Keith;Macosko Jed C.;Gagliano Jason;Guthold Martin;Cubicciotti Roger |
分类号 |
G01N33/543 |
主分类号 |
G01N33/543 |
代理机构 |
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代理人 |
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主权项 |
1. A device comprising:
(a) a spatially addressable array, said array comprising a plurality of separate and discrete locations thereon; (b) a plurality of different oligomers operably connected to said spatially addressable array at different ones of said separate and discrete locations; (c) a tag sequence which is complementary to, and is hybridized to, each of said oligomers; and (d) a candidate chemical operably connected to each of said tag sequences, wherein each of said discrete locations is a unique identifier for its corresponding oligomer; and wherein said tag sequence is a unique identifier for its connected candidate chemical. |
地址 |
Winston-Salem NC US |