| 发明名称 |
METHODS FOR TREATING HOMOZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA |
| 摘要 |
The present invention relates to methods for treating homozygous familial hypercholesterolemia using antibodies against proprotein convertase subtilisin/kexin type 9 (PCSK9). |
| 申请公布号 |
US2015004174(A1) |
申请公布日期 |
2015.01.01 |
| 申请号 |
US201414316587 |
申请日期 |
2014.06.26 |
| 申请人 |
AMGEN INC. |
发明人 |
Wasserman Scott;Scott Robert Andrew Donald;Stein Evan A. |
| 分类号 |
C07K16/40 |
主分类号 |
C07K16/40 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of lowering serum LDL cholesterol in a patient diagnosed with homozygous familial hypercholesterolemia comprising administering at least one anti-PCSK9 antibody to the patient in need thereof at a dose of about 120 mg to about 3000 mg, thereby lowering said serum LDL cholesterol level by at least about 10%. |
| 地址 |
Thousand Oaks CA US |
