| 发明名称 |
METHODS FOR PROGRAMMING DIFFERENTIATED CELLS INTO HEMATOPOIETIC STEM CELLS |
| 摘要 |
The disclosure relates to the development of methods for making hematopoietic stem cells from differentiated cells by introducing and expressing transcription factors. More particularly, the disclosure provides methods for redirecting differentiated cells to a hematopoietic stem cell state or to a hemogenic endothelial cell state by direct programming with specific combinations of transcription factors. |
| 申请公布号 |
US2015004145(A1) |
申请公布日期 |
2015.01.01 |
| 申请号 |
US201314374639 |
申请日期 |
2013.01.30 |
| 申请人 |
Icahn School of Medicine at Mount Sinai |
发明人 |
Lemischka Ihor R.;Moore Kateri;Pereira Carlos Filipe |
| 分类号 |
C12N5/0789;G01N33/50 |
主分类号 |
C12N5/0789 |
| 代理机构 |
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代理人 |
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| 主权项 |
1. A method for programming a differentiated cell into a hematopoietic stem cell, the method comprising introducing a combination of transcription factors in the differentiated cell, wherein the combination comprises GATA binding protein 2 (GATA2), growth factor independent 1B (GFI1B), and c-Fos. |
| 地址 |
New York NY US |
