DIAGNOSIS OF MELANOMA BY NUCLEIC ACID ANALYSIS

摘要

The present invention provides methods for diagnosing melanoma and/or solar lentigo in a subject by analyzing nucleic acid molecules obtained from the subject. The present invention also provides methods for distinguishing melanoma from solar lentigo and/or dysplastic nevi and/or normal pigmented skin. The methods include analyzing expression or mutations in epidermal samples, of one or more skin markers. The methods can include the use of a microarray to analyze gene or protein profiles from a sample.

主权项

1. A method for diagnosing melanoma in a subject, comprising:
(a) detecting nucleic acids expressed by two or more genes comprising: ACTN4, LINC00518, CMIP, TTC3, TMEM80, HLA-C, or PRAME in a sample of a skin lesion from the subject; and (b) characterizing the skin lesion as melanoma, based on the detection of the nucleic acids, thereby diagnosing the presence or absence of melanoma.