发明名称 |
OSTEOPONTIN ISOFORM A INHIBITORS AND METHODS OF USE |
摘要 |
The present invention relates to a therapeutic comprising an osteopontin isoform a (“OPNa”) inhibitor where the OPNa inhibitor blocks activity of extracellular OPNa exon 4. The OPNa inhibitor is selected from the group consisting of (i) an exon-4 specific antibody or binding portion thereof; (ii) a peptide mimic of OPNa exon 4 or a fragment thereof; (iii) a nucleic acid aptamer that specifically binds to OPNa exon 4 or a fragment thereof; and (iv) a peptide inhibitor that binds to OPNa exon 4 or a fragment thereof. The present invention also relates to methods of inhibiting tumor growth and/or metastasis in a subject, treating a subject with chemotherapeutic resistance, and methods of increasing tumor cell sensitivity to a cancer therapeutic by administering an OPNa inhibitor according to the present invention. |
申请公布号 |
US2015004157(A1) |
申请公布日期 |
2015.01.01 |
申请号 |
US201314378381 |
申请日期 |
2013.02.13 |
申请人 |
Pass Harvey I.;Donington Jessica S.;Goparaju Chandra M. |
发明人 |
Pass Harvey I.;Donington Jessica S.;Goparaju Chandra M. |
分类号 |
A61K38/19;C07K14/52;A61K45/06;C07K16/24;C12N15/115 |
主分类号 |
A61K38/19 |
代理机构 |
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代理人 |
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主权项 |
1. A therapeutic comprising:
an osteopontin isoform a (“OPNa”) inhibitor, wherein the OPNa inhibitor blocks activity of extracellular OPNa exon 4 and is selected from the group consisting of: (i) an exon-4 specific antibody or binding portion thereof; (ii) a peptide mimic of OPNa exon 4 or a fragment thereof; (iii) a nucleic acid aptamer that specifically binds to OPNa exon 4 or a fragment thereof; and (iv) a peptide inhibitor that binds to OPNa exon 4 or a fragment thereof. |
地址 |
Bronxville NY US |