COMBINED PHARMACEUTICAL FORMULATION CONTAINING DIACEREIN

摘要

The present invention relates to a combined pharmaceutical formulation having therapeutic anti-inflammatory, analgesic, antipyretic and osteoarthritis activities. From another perspective, the present invention relates to a new solid oral dosage form comprising a pharmaceutically effective amount of NSAID and a pharmaceutically effective amount of diacerein and the solid oral dosage form according to the present invention is preferably in the form of tablet and more preferably in the form of multi-layer tablet.

主权项

1. A solid oral multi-layer tablet in the form of a sandwich, wherein it comprises:
i) a first layer containing a propionic acid derivative NSAID as the first active agent and pharmaceutically acceptable excipient or excipients; ii) a second layer containing diacerein as the second active agent and pharmaceutically acceptable excipient or excipients; and iii) a barrier layer positioned between these two layers and comprising pharmaceutically acceptable excipient or excipients.