RSV G PROTEIN SPECIFIC ANTIBODIES

摘要

The disclosure relates to human isolated, synthetic or recombinant antibodies or functional parts thereof, specific for the RSV G protein. Antibodies specific for the RSV G protein are particularly suitable for counteracting RSV and symptoms, such as inflammation, resulting from an RSV infection. The disclosure further relates to the use of such RSV G-specific antibodies for diagnosis of an RSV infection and as a medicament and/or prophylactic agent for, at least in part, treating or alleviating symptoms of a Respiratory Syncytial Virus infection and/or a Respiratory Syncytial Virus related disorder.

主权项

1. A human isolated, synthetic or recombinant antibody or functional part thereof, or immunoglobulin or functional equivalent thereof, capable of binding to a G protein of Respiratory Syncytial Virus (RSV), which antibody or functional part or immunoglobulin or functional equivalent is capable of potentiating RSV neutralizing activity of an antibody capable of binding an F protein of RSV, the antibody or functional part or immunoglobulin or functional equivalent having a combination of CDR sequences selected from the group consisting of:
SEQ ID NO: 1 and SEQ ID NO: 19 and SEQ ID NO: 37 and SEQ ID NO: 55 and SEQ ID NO: 73 and SEQ ID NO: 91; and SEQ ID NO: 2 and SEQ ID NO: 20 and SEQ ID NO: 38 and SEQ ID NO: 56 and SEQ ID NO: 74 and SEQ ID NO: 92; and SEQ ID NO: 3 and SEQ ID NO: 21 and SEQ ID NO: 39 and SEQ ID NO: 57 and SEQ ID NO: 75 and SEQ ID NO: 93; and SEQ ID NO: 5 and SEQ ID NO: 23 and SEQ ID NO: 41 and SEQ ID NO: 59 and SEQ ID NO: 77 and SEQ ID NO: 95; and CDR sequences that are at least 70% identical to the sequences of any of these combinations.