METHODS AND COMPOSITIONS FOR INCREASING RNA INTERFERENCE

摘要

The present invention relates to compositions containing a combination of a first active component comprising one or more sulfated polysaccharides and/or glycosaminoglycans and a second active component comprising one or more RNAi-inducing molecules, and methods for using these compositions to enhance double-stranded RNA (dsRNA)-mediated gene silencing in pest or pathogen species. The invention further relates to methods for controlling pests or pathogens, methods for preventing pest infestations or pathogen infections and methods for knocking down gene expression in pests or pathogens using the compositions and methods of the invention.

主权项

1. A method for increasing a RNA interference (RNAi) effect of a molecule or composition that reduces expression of a selected gene or genes by RNA interference in cell(s) or an organism comprising
contacting the cell(s) or organism with (1) a first active component comprising an amount of one or more sulfated polysaccharides and/or glycosaminoglycans that is effective to enhance the RNAi effect of a molecule(s) or a composition and (2) a second active component comprising a molecule(s) or a composition that reduces expression of a selected gene or genes by RNA interference.