发明名称 |
ACTIVITY-BASED PROBE COMPOUNDS, COMPOSITIONS, AND METHODS OF USE |
摘要 |
Activity-based probe compounds for use in labeling a cysteine protease are provided. The compounds are targeted to the protease through a specific targeting element. The compounds additionally include a detectable element, such as a fluorescent label, a radiolabel, or a chelator. In some cases, the compounds additionally include a quenching element that is released upon reaction with the protease. Also provided are compositions comprising the compounds and methods for using the compounds, for example in labeling a protease in an animal and in visualizing a tumor in an animal. |
申请公布号 |
WO2014145257(A3) |
申请公布日期 |
2014.12.31 |
申请号 |
WO2014US29990 |
申请日期 |
2014.03.15 |
申请人 |
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY |
发明人 |
BOGYO, MATTHEW, S.;VERDOES, MARTIJN |
分类号 |
C12Q1/37;A61B5/00;C07D401/00 |
主分类号 |
C12Q1/37 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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