发明名称 |
SEPARATION OF RECOMBINANT POLYCLONAL ANTIBODY MULTIMERS WITH MINIMAL SEPARATION OF MONOMERS |
摘要 |
The invention provides a method tor removing multimers from a preparation of recombinant polyclonal antibodies (rpAbs) while maintaining the ratio of monomers within a narrow range. The invention provides a method of separating recombinant polyclonal antibody multimers with minimal separation of monomers comprising subjecting a mixture comprising a plurality of monoclonal antibodies to at least one separation process selected from the group consisting of multi-modal chromatography, apatite chromatography, and hydrophobic interaction chromatography thereby producing an antibody monomer preparation that is substantially free of multimers. |
申请公布号 |
WO2014209508(A1) |
申请公布日期 |
2014.12.31 |
申请号 |
WO2014US37684 |
申请日期 |
2014.05.12 |
申请人 |
MEDIMMUNE, LLC |
发明人 |
HUNTER, ALAN;PABST, TIMOTHY;WANG, JIHONG;WANG, XIANGYANG;LIU, HONGJI |
分类号 |
C07K16/00 |
主分类号 |
C07K16/00 |
代理机构 |
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代理人 |
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地址 |
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