Mice that comprise a replacement of endogenous mouse IL-6 and/or IL-6 receptor genes are described, and methods for making and using the mice. Mice comprising a replacement at an endogenous IL-6R± locus of mouse ectodomain-encoding sequence with human ectodomain-encoding sequence is provided. Mice comprising a human IL-6 gene under control of mouse IL-6 regulatory elements is also provided, including mice that have a replacement of mouse IL-6-encoding sequence with human IL-6-encoding sequence at an endogenous mouse IL-6 locus.
申请公布号
EP2818478(A1)
申请公布日期
2014.12.31
申请号
EP20140177863
申请日期
2012.10.29
申请人
REGENERON PHARMACEUTICALS, INC.
发明人
WANG, LI-HSIEN;DORE, ANTHONY, T.;STEVENS, SEAN;MURPHY, ANDREW, J.