TRAPPING MAGNETIC NANOPARTICLES BY CYCLIN B1 MRNA SCAFFOLD

摘要

Trapping magnetic nanoparticles by Cyclin Bl mRNA scaffold relates to a novel method for trapping magnetic nanoparticles inside cancer cells. Trapping takes place in two steps; establishment of a scaffold from Cyclin Bl mRNA and assembly of magnetic nanoparticles on this scaffold. First, an antisense oligonucleotide, specific for Cyclin Bl mRNA, is modified with a peptide that is lipidated by cellular enzymes leading to indirect association of Cyclin Bl mRNA with plasma membrane. Then magnetic nanoparticles, coated with ligands specific for Cyclin Bl mRNA, will be trapped by the scaffold(s). Trapped magnetic nanoparticles could be applied in thermal ablation of cancer cells when exposed to an alternative magnetic field.