摘要 |
Disclosed are compounds of Formula (I); and salts thereof, wherein:Formula (II); Q is: R1 is -C(CH3)2OH, -NHC(=0)C(CH3)3, -N(CH3)2, or -CH2Rd; R2 is CI or -CH3; R3 is H, F, or -CH3; Ra is H or -CH3; Rb is H, F, CI, or -OCH3 Rc is H or F; and Rd is -OH, -OCH3, -NHC(=0)CH3, or fORMULA (III), Also disclosed are methods of using such compounds as inhibitors of Bruton's tyrosine kinase (Btk), and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease. |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
KO, SOO SUNG;BATT, DOUGLAS A.;BERTRAND, MYRA BEAUDOIN;DELUCCA, GEORGE V.;LANGEVINE, CHARLES M.;LIU, QINGJIE;SRIVASTAVA, ANURAG S.;WATTERSON, SCOTT HUNTER |