NOVEL PIPERAZINE ANALOGS AS BROAD-SPECTRUM INFLUENZA ANTIVIRALS

摘要

A compound of Formula I is set forth, including pharmaceutically acceptable salts thereof: wherein Het is a 5 or 6-membered heterocycle with—N,—O, or—S adjacent to the—Ar substituent or adjacent to the point of attachment for the—Ar substituent; Ar is aryl or heteroaryl; R is—CH3,—CH2F, or—CH═CH2; W is—NO2,—Cl,—Br,—CHO,—CH═CH2, or—CN; X is—Cl,—CH3, or—CN; Y is—CH or—N; and Z is C1-C6 alkyl, C3-C6 cycloalkyl, substituted aryl, substituted heteroaryl, OR1, or NHR1, wherein R1 is selected from the group of H, aryl, heteroaryl, C1-C6 alkyl and C3-C6 cycloalkyl. This compound is useful in compositions for the prevention and treatment of influenza virus.