摘要 |
Methods of delivering therapeutic agents by administering compositions including a bacterial collagen-binding polypeptide segment linked to the therapeutic agent to subjects in need of treatment with the therapeutic agent are provided. In these methods, the therapeutic agent is not a PTH/PTHrP receptor agonist or antagonist, basic fibroblast growth factor (bFGF) or epidermal growth factor (EGF). The bacterial collagen-binding polypeptide segment delivers the agent to sites of partially untwisted or under-twisted collagen. Methods of treating collagenopathies using a composition including a collagen-binding polypeptide and a PTH/PTHrP receptor agonist are also provided. In addition, methods of treating hyperparathyroidism, and hair loss using compositions comprising a collagen binding polypeptide and a PTH/PTHrP receptor agonist are provided. Finally, methods of reducing hair regrowth by administering a composition including a collagen binding polypeptide and a PTH/PTHrP receptor antagonist are provided. |
申请人 |
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS;KITASATO UNIVERSITY;MONTEFIORE MEDICAL CENTER |
发明人 |
SAKON, JOSHUA;PHILOMINATHAN, SAGAYA, THERESA, LEENA;KATIKANENI, RANJITHA;MATSUSHITA, OSAMU;PONNAPAKKAM, TULASI;KOIDE, TAKAKI;GENSURE, ROBERT, C. |