Method for producing a basic substance

摘要

A process for producing a basic substance according to a fermentation technique, including culturing a microbe having the potency of producing a basic substance in a fermentation tank containing a liquid culture medium to thereby produce and accumulate the basic substance in the culture medium, characterized in that during at least a partial period of the entire culturing step, the ammonia concentration of the culture medium is regulated so as to fall within a given concentration range, thereby reducing the amount of sulfate ion and/or chloride ion sued as a counter ion of the basic substance.