LABELED PKG-1-ALPHA-BINDING COMPOUNDS AND THEIR USE IN IMAGING AND QUANTIFYING PAIN

摘要

The present invention relates to the use of compounds that selectively bind to activated protein kinase G1 alpha for imaging the anatomic basis for chronic pain. Such imaging may also be used to objectively quantify chronic pain. Specifically, fluorine-18 and carbon -11 labeled NOP compouds, [18F] NOP46 and [11 C]NOP46, are disclosed for use as imaging agents for detecting and quantifying neuropathic pain.