6-SUBSTITUTED INDOLE-3-CARBOXYLIC ACID AMIDE COMPOUNDS HAVING SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR ANTAGONIST BIOLOGICAL ACTIVITY

摘要

The invention provides compounds represented by the formula I, each of which compounds may have sphingosine-1-phosphate receptor agonist and/or antagonist biological activity: and wherein the variables Y, R⁴, n, o, A, A¹, A², X, Z, R¹, R³, R², p, q and r are as defined in the specification. These compounds are useful for treating a disease or condition selected from the group consisting of glaucoma, dry eye, angiogenesis, cardiovascular conditions and diseases, and wound healing