Disposable chromatography valves and system

摘要

Described is a disposable valve that includes an actuation layer operationally linked to a flexible diaphragm; a valving layer operationally linked to the flexible diaphragm; and a connection layer operationally connected to the valving layer; wherein the valving layer and the connection layer have a corresponding plurality of channels passing therethrough, and the channels define at least one fluid flow path, and the flexible diaphragm is movable between a first open position wherein fluid can flow through the fluid flow path, and a second closed position wherein fluid cannot flow through the fluid flow path. Chromatographic systems incorporating a plurality of such valves, optionally integrated into a unitary valve block, are also described.

主权项

1. A liquid chromatography system comprising:
a valve comprising: an actuation layer operationally linked to a flexible diaphragm; a valving layer operationally linked to the flexible diaphragm; and a connection layer operationally connected to the valving layer; wherein the valving layer and the connection layer have a corresponding plurality of channels passing therethrough, wherein the channels define at least one fluid flow path, and wherein the flexible diaphragm is movable between a first open position wherein fluid can flow through the fluid flow path, and a second closed position wherein fluid cannot flow through the fluid flow path; the actuation layer, valving layer, and connection layer defining a disposable valve that does not include an actuator, whereby the valve may be disposed of without disposing of the actuator; operationally linked to a peristaltic pump.